Major enterprises in the industry:, giant creatures, bimei creatures, etc.

Core data of this article:The market size of collagen in China and the number of patent applications related to collagen.

1. Overview of Collagen Industry

— — Definition, classification and application

Collagen, also known as collagen, is a spiral fibrous protein twisted by three peptide chains. Collagen, as a kind of fibrin in human body, accounts for 25%-33% of human protein content, and mainly exists in skin, muscle and bone, which plays a role in improving the elasticity of skin and muscle, enhancing the combination of calcium and bone cells, and protecting bone health. Because of its unique biological characteristics, collagen can be widely used in beauty, clinical medicine, food, chemical industry and other fields. With the expansion of demand for skin care, beauty, nutrition and health care in China, the market demand for collagen will usher in a continuous expansion stage.

At present, collagen products on the market in China can be mainly divided into two types according to the production methods: animal-derived collagen and sufficient collagen, among which animal-derived collagen has mature technology and low cost, but there are risks of immune rejection and allergy; Although the cost of recombinant collagen is high, the product has high activity and no risk of infection, and its market share is gradually increasing.

2) Analysis of industrial chain of collagen industry

The upstream products of collagen industry mainly include animal raw materials such as bovine achilles tendon needed for producing animal-derived collagen and raw materials such as yeast extract powder and strains needed for producing recombinant collagen. The middle reaches are producers of collagen raw materials, and the lower reaches are various application fields of collagen. It is worth mentioning that in the collagen industry, most enterprises have both the ability to extract collagen raw materials in the middle reaches and the ability to process downstream products.

The upstream enterprises in the collagen industry include manufacturers of raw materials for collagen preparation, such as, bio, etc., and the middle and lower reaches are manufacturers of raw materials for collagen extraction and products, including Chuanger Bio, Juzi Bio, Jinbo Bio, etc.

2. The development of collagen industry in China: The technology of recombinant collagen is developing rapidly.

In 1981, Zyderm, the first bovine collagen filling product in history, was officially approved, which was mainly used to improve senile wrinkles and was all the rage in Europe and America. By 1995, there were about one million beauty seekers in the world. At the end of the 20th century, mad cow disease swept the world, which caused a great blow to bovine collagen products. Researchers paid more attention to pig collagen products and fish collagen products. In 2003, Professor Fan Daidi and others successfully cultivated human-like collagen, and the recombinant collagen began to develop rapidly.

3. China collagen industry policy background: policy blessing.

China government began to manage the collagen industry in 2008; In 2008, the State Food and Drug Administration issued the Notice on the Classification and Definition of Collagen Cartilage Carrier and other products, which clearly stated that "recombinant human acellular dermal matrix: containing extracellular matrix components such as collagen, fibronectin and laminin, can temporarily cover skin wounds, protect and promote wound repair, and is used for the repair of fault or small-area full-thickness skin defects. This product is managed as a Class III medical device. "

With the progress of collagen-related technology and the iteration of products, the state has also adjusted relevant policies. In April, 2021, National Medical Products Administration issued the Principles for Classification and Definition of Recombinant Collagen Medical Products, which stipulated that "when recombinant collagen products are used as medical dressings, if the products cannot be absorbed by the human body and are used for non-chronic wounds, they shall be managed according to the second category of medical devices." Changed the previous regulations that collagen products were managed in accordance with the third category of devices.

4. Analysis of the development status of collagen industry in China.

— — The market scale of collagen industry in China has exceeded 20 billion yuan.

With the continuous development of "Yan value economy", the scale of China’s collagen market is expanding. According to Jost Sullivan’s estimation, from 2017 to 2021, the market scale of collagen products in China increased from 9.7 billion yuan to 28.7 billion yuan, with a compound annual growth rate of 31.15%. From 2017 to 2021, the average annual compound growth rate of recombinant collagen market reached 63.8%, which was much higher than the growth rate of animal-derived collagen market.

2) Application of collagen products: Medical health is the main application field.

Collagen has a wide range of downstream applications, including medical treatment, food and health care products, cosmetics, medical beauty, chemical industry, feed and other fields. In 2020, 48% of collagen products in China will be used in medical and health fields (including medical beauty), 32% in food fields, and only 21% in cosmetics and other fields.

Recombinant collagen is widely used in medical beauty and skin care products because of its low rejection and no risk of carrying animal-derived viruses. According to Jost Sullivan’s data, in 2021, 29% of recombinant collagen in China will be used for functional skin care products, 31% for medical dressings and 35% for general skin care products.

3) The number of patent applications for collagen industry in China has increased rapidly.

From 2012 to 2021, the number of patent applications related to collagen in China increased rapidly, and it has exceeded 1800 in 2020 and 2021, indicating that the domestic collagen industry has made rapid technological progress in recent years.

4) The investment and financing of collagen industry in China declined.

Although the market scale of collagen products has gradually expanded in recent years, from the perspective of investment and financing events, the popularity of the collagen industry is declining. In 2016, there were three investment and financing events in the collagen industry, while there was only one investment and financing event in the industry in 2020 and 2021.

5. Analysis of the competitive pattern of collagen industry in China.

— — Regional competition pattern: North China and Guangdong have the largest number of collagen enterprises.

At present, the collagen production enterprises in China have strong aggregation, and Hebei and Shandong in North China are the provinces with the largest number of collagen production enterprises in China. Among them, collagen enterprises in Hebei mainly produce collagen casings for food. In addition, there are many collagen production enterprises in Guangdong.

2) Enterprise competition pattern: There are many participants in the collagen industry in China.

At present, the leading enterprises of collagen in China mainly focus on collagen raw materials, medical and health collagen products and collagen food. Representative enterprises in the field of collagen raw materials include Hainan Huayan Bio, Dongbao Bio and Baiyang Co., Ltd.; Representative enterprises in the medical and health field are Chuanger Bio, Jinbo Bio, Giant Bio,; Collagen food fields include, Haili Province, SWISSE, etc.

6. Development prospect and trend forecast of collagen industry in China.

— — The food sector has become an important growth pole.

Collagen contains a variety of amino acids, including unique hydroxyproline and hydroxylysine. Hydroxylysine is the necessary material basis of human articular cartilage tissue, which cannot be synthesized by human body and needs to be supplemented from food. In Europe, America and other countries, collagen has become a popular food that people like very much. In Asia, China and Japan have had the habit of eating skin jelly and fish scale cream since ancient times, and supplementing collagen has a long history. Especially in Japan, collagen, as a commonly used food additive, has formed a huge market. In China, with the strategy of "Healthy China" put forward, residents’ awareness of health care has been further enhanced, and the demand for food containing collagen will continue to increase. It is expected that the food field will become an important growth pole of the collagen market in the future.

2) Recombinant collagen has become the mainstream of the market.

Recombinant collagen has the advantages of no rejection risk and no risk of animal-derived virus infection, and is more suitable for food and medical and health fields. According to Jost Sullivan’s prediction, the market scale of recombinant collagen in China will surpass that of animal-derived collagen in 2024. By 2027, the market size of collagen in China will exceed 150 billion yuan, of which the market size of recombinant collagen will exceed 100 billion yuan.

For more research and analysis of this industry, please refer to Foresight Industry Research Institute. At the same time, Foresight Industry Research Institute also provides solutions such as industrial big data, industrial research, policy research, industrial chain consultation, industrial atlas, industrial planning, park planning, industrial investment attraction, IPO fundraising feasibility study, IPO business and technology writing, and IPO working paper consultation.